Southern Cheesy Chicken Spaghetti Casserole

If you’re craving a comforting, creamy dinner that brings a touch of Southern charm to your table, this Southern Cheesy Chicken Spaghetti Casserole is your new go-to. Bursting with tender chicken, gooey cheese, and perfectly cooked spaghetti, this casserole recipe combines simple ingredients into a dish that’s both hearty and irresistible. Whether for a busy weeknight or a cozy family gathering, this casserole is quick to make and sure to satisfy everyone around the table.

Why You’ll Love This Recipe

• Comfort in every bite: The creamy cheese sauce and tender chicken create a warm, satisfying meal that feels like a big hug.
• Easy to prepare: With straightforward steps and pantry-friendly ingredients, it’s perfect for cooks of all levels.
• Family-friendly flavors: Mild, cheesy, and filling, it’s a crowd-pleaser for kids and adults alike.
• Make-ahead magic: Prepare in advance for busy nights and enjoy a delicious home-cooked dinner without the hassle.
• Great leftover potential: Tastes even better the next day, making meal planning a breeze.

Ingredients You’ll Need

Every ingredient in this Southern Cheesy Chicken Spaghetti Casserole plays a crucial role in making the dish creamy, flavorful, and perfectly textured. From the tender chicken to the cheesy sauce and spaghetti, these essentials come together to create that classic Southern comfort vibe.

• Chicken breast or thighs: Tender, juicy protein that soaks up the creamy sauce beautifully.
• Spaghetti noodles: Cooked al dente for the ideal texture that holds the sauce well.
• Cream cheese: Adds rich creaminess and depth to the sauce.
• Cheddar cheese: Gives cheesy sharpness and gooey meltiness to the casserole.
• Heavy cream or milk: Balances the cheeses and makes the sauce silky smooth.
• Butter: Adds richness and helps build the sauce base.
• Garlic and onion powder: Adds a savory kick without overpowering the dish.
• Salt and pepper: Essential seasoning to enhance all the flavors.
• Optional extras – green onions or bell peppers: For a pop of color and subtle crunch.

Variations for Southern Cheesy Chicken Spaghetti Casserole

This recipe is incredibly versatile, making it easy to adapt to your pantry staples, diet preferences, or flavor cravings. Don’t hesitate to experiment and make it your own!

• Spicy twist: Add diced jalapeños or a dash of hot sauce to the sauce for a spicy Southern kick.
• Vegetable boost: Mix in cooked broccoli, mushrooms, or peas for extra nutrition and texture.
• Different cheese blends: Swap cheddar for mozzarella, Monterey Jack, or pepper jack for varied cheesiness.
• Chicken substitutes: Use rotisserie chicken or turkey for convenience or a leaner option.
• Low-carb adaptation: Replace spaghetti with spiralized zucchini or shirataki noodles to cut carbs.

How to Make Southern Cheesy Chicken Spaghetti Casserole

Step 1: Prepare the Chicken

Start by cooking your chicken breasts or thighs in a skillet with a bit of butter or oil until golden brown and cooked through. Season lightly with salt, pepper, and onion powder. Once done, shred or dice the chicken into bite-sized pieces and set aside.

Step 2: Cook the Spaghetti

Boil your spaghetti noodles according to package instructions until al dente. Once cooked, drain and set the pasta aside, making sure it doesn’t stick by tossing it lightly with a bit of butter or oil.

Step 3: Make the Cheese Sauce

In the same skillet, melt butter over medium heat, then add cream cheese and stir until melted and creamy. Slowly pour in the heavy cream or milk while stirring continuously. Add garlic powder, onion powder, salt, and pepper. Once smooth, stir in shredded cheddar cheese until fully melted and the sauce is thick and creamy.

Step 4: Combine Ingredients

Return the shredded chicken to the skillet with the cheese sauce, then gently fold in the cooked spaghetti until well coated. If you want, toss in chopped green onions or bell peppers for a fresh crunch and vibrant color.

Step 5: Bake the Casserole

Transfer the mixture into a greased casserole dish. Sprinkle extra cheddar cheese on top for a bubbly, golden finish. Bake at 350°F (175°C) for 20-25 minutes until the cheese is melted and slightly golden.

Pro Tips for Making Southern Cheesy Chicken Spaghetti Casserole

• Use freshly shredded chicken: It absorbs the sauce better and keeps the dish tender.
• Don’t overcook the pasta: Slightly undercook spaghetti as it finishes baking in the casserole.
• Let it rest: Allow the casserole to rest for 5-10 minutes after baking to firm up for easy serving.
• Cheese choices matter: Sharp cheddar gives bold flavor, but blending in mozzarella softens the intensity.
• Add a crunchy topping: Sprinkle breadcrumbs mixed with melted butter for extra texture on top before baking.

How to Serve Southern Cheesy Chicken Spaghetti Casserole

Garnishes

Fresh herbs like chopped parsley or green onions add brightness and a lovely color contrast that elevates the dish’s appearance and flavor. A sprinkle of red pepper flakes can add a gentle heat if you enjoy that extra zing.

Side Dishes

Pair this casserole with a crisp side salad dressed in tangy vinaigrette to cut through the richness. Roasted or steamed green veggies like broccoli, green beans, or asparagus offer a delicious balance and added nutrition.

Creative Ways to Present

Serve Southern Cheesy Chicken Spaghetti Casserole in individual ramekins for a charming, personalized touch. Alternatively, layer it in a trifle-style glass dish for a visually appealing presentation at potlucks or family dinners.

Make Ahead and Storage

Storing Leftovers

Keep leftovers in an airtight container in the refrigerator for up to 3-4 days. The casserole’s flavors will deepen overnight, making it even tastier the next day.

Freezing

This casserole freezes well: cool completely before transferring to a freezer-safe container. Freeze for up to 3 months and thaw overnight in the fridge before reheating.

Reheating

Reheat leftovers in the oven at 350°F (175°C) covered with foil to keep the moisture in, or microwave individual portions until warmed through, stirring halfway for even heating.

FAQs

Can I use rotisserie chicken for this recipe?

Absolutely! Rotisserie chicken is a great shortcut — just shred it and add it directly to the sauce, saving time and boosting flavor.

What’s the best cheese to use?

Sharp cheddar is classic for that signature Southern flavor, but mixing in mozzarella or Monterey Jack can create a deliciously creamy blend.

Can I make this recipe dairy-free or vegan?

Yes, substitute dairy cheese with plant-based mozzarella or cheddar alternatives, and swap cream cheese and heavy cream with dairy-free versions or coconut cream to keep it creamy.

How do I make the casserole less rich?

Use low-fat milk instead of heavy cream and reduce the amount of cream cheese while adding extra seasoning to keep flavor balanced.

Is this casserole freezer-friendly?

Definitely! It freezes wonderfully, making it an ideal prep-ahead meal during busy weeks or for family dinners on the go.

Final Thoughts

Wrap yourself in the creamy, cheesy goodness of this Southern Cheesy Chicken Spaghetti Casserole — a dish that’s simple to make yet packed with comforting Southern flavor. Give this recipe a try and discover why it’s a beloved classic that brings smiles and satisfied appetites every time.

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